According to the World Health Organisation, four out of five cardiovascular diseases (CVDs) deaths are due to heart attacks and strokes. Asymptomatic vascular damage accumulates for years before patients are identified and subjected to therapeutic measures. The SysVASC project seeks to provide a comprehensive systems medicine approach to elucidate pathological mechanisms for CVD, which will yield molecular targets for therapeutic intervention.
The CVD Knowledgebase (CVDKB) gathers and integrates a large amount of data from omics experiments that was scattered over many publications or held in supplemental data. At the core of CVDKB is the CVD ontology (CVDO), which is built in OWL and JSON-LD.
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